Customer Reviews
98% of Reviewers
recommend this product
4.8 / 5
85 Reviews
Much better alternative to Name brand

During the shortages of 2021 we were unable to find a reasonably priced version of this medication. The only place to get it was at a vet where it was double the normal price on amazon, which was out of stock. Then Vetito stepped up with their own brand and really saved the day. They charge much less than the name brand and it has been very effective with our dog. As of her last vet visit, her liver levels are in check. Thank you so much for recognizing an industry gap and not taking advantage of people.

Great substitute for D*****

Great substitute for D***** (product name hidden) and a reasonable price. Cost less than D***** too and gives my dog the liver support he needs. Vetito is quick to ship too!

Very Good Service

Got this to replace problems with the "brand name" which was very hard to get. My dog really needs this medication, and I am very happy I could get it, and it came very, very fast!

Very happy with this alternative to D*****. Dogs find it palatable in a "pill pocket" and take it without resisting.

Great product!

I was so happy to find this supplement! It has the same ingredients as my dog’s current one that has been on back order. He has liver issues and this helps keep him healthy! Great price and service.

Silymarin Advanced for small dogs

I replaced Denamarin with this product as I wasn't able to get it anymore and have been happy with it.
They shipped quickly and they were very nice when talking to them on the phone.

D***** Alternative

Overall experience is excellent! Just as good or better than brand name. Better service and pricing adds better value.

Great product

Just as good as D***** and cheaper!

Cheaper than D***** !!

Better and cheaper alternative to D***** (product name hidden). Happy with results. Took my dog in for blood work and was happy to report he is stable.

Silymarin advanced

I purchased SilymarinAdvanced
225 mg, good price and the delivery time was good.
I just wish the tablets were oblong shape instead of round. But overall all good.


I have used this product for several months. It is much more affordable than the leading brand.

My dog seems to be OK with this product as long as he doesn't smell it! I use can cheese or peanut butter to hide it. Product says take with no food.

silymarin advanced

Tried your product again because D***** (product name hidden) not available! Same problem as before: my poor Daisy's blood sugar went way high!!! So, stuck between a rock and a hard place, and your folks can't tell me if there might be a carbohydrate component that could be causing this. Y'all are no help at all!!!


Workes very well for my dog


Seems to be working fine for my dog

Silymarin Advanced

Equal to or better than D***** (product name hidden) at a much better price!

Works Great

Equal to or better than D***** (product name hidden) at a much better price!

Silymarin Advanced


Equal to D***** (product name hidden) at better price


Great! Cheaper than name brand and smaller tablet, too!

Good price fairly quick delivery.
I recommend


Seems to not cause any adverse effects so far. Tablets can be chewed (per my query to Vetito), dog will sometimes spit it out. May need to work on the palatability of this.

Cheaper but not Cheap

The active ingrediants almost the same as the name brand but much less money.

Less expensive.

Best deal on an essential product!

SilymarinAdvanced is a product that I will be sticking with. When I could no longer get the comparable traditional product, VetPerfect met the need. This product is better and more reasonably priced. I'm sticking with it!

Great supplement

I purchased this when I was unable to get the name brand liver supplement my dog has been on. I find it easier to give, it's a smaller pill. Also, it doesn't make my fingers all blue when he tries to spit it back out like the other. This is my third bottle, and Turbo is doing great.

Judith Riedel

Has all the ingredients of the more expensive brand, and is easier to give.

Silymarin Advanced

Love this product! Generic version of liver support product & it is chewable. Much easier to administer-don’t have to coat with peanut butter like other pills & great price.

Ran it by vet before buying

Our dog has been on D***** (product name hidden) for several years so I asked our vet if it was ok to switch to Silymarin Advanced and she agreed after reviewing the ingredients.

D***** (product name hidden)

I’m very happy with their generic form of this liver support medication. It comes on time and is less expensive as well.

Pills arrived fast and at a good price. Very happy with service
Did not receive my 10% off on second order.

So happy for this replacement to D***** (product name hidden)

After hair pulling earlier this year due to the D***** shortage this is a God send. I did get the earlier generic from Vetito but it required giving our pupper 2 pills, not an easy task I assure you as she spit each one across the kitchen as given, it took numerous attempts. So far so good with this new alternative, smaller tablet and obviously easier to swallow for her. We are on our second bottle and all seems well.


Great product

A Good Product

Because D***** (product name hidden) has been out of stock usually, this has been a good substitute. Thanks

Silymarin advanced

I had a hard time finding D***** (product name hidden) for my Dalmatian Roxy. I tried the 2 bottle substitution that vetito suggested. She didn’t like the taste and I had a hard time getting her to take it. Once the Silymarin Advanced came out I tried it. She loves it and I plan on keeping her on it. Thanks Vetito for this product. Roxy’s mom


Great for my 14 yr. Old dog

Silymarin/Advanced 90 mg 30 tablets

I tablet instead of two prior orders and this has been upgraded with 1 tablet. I love this to help my dog plus the price is right!!! Thank you for fast delivery too.

Dog preferred

My Maximus tolerates this pill over D***** (product name hidden). The other pill he would constantly spit out or he would pretend to swallow and I would find it hidden in his bedding later. I like that it doesn't have that nasty blue coating and the pill is smaller but potent. My Max is eating more, vomiting less and gaining weight.
We are extremely pleased and grateful.

Silymarin 425 mg

Excellent product. My dog was getting really resistant to taking the blue pills from my vet. He takes these easily!

silmarin tablets

great product, really helped my dogs liver function. great company and quick delivery. price was amazing. love love love. this was my second time purchasing and always a good experience. they are also very knowledgeable.

Silymarin Advanced

Could not find D***** (product name hidden) medium tablets, trying Silymarin Advanced. Jury is out on how well this working.

Completely thankful

It is with a broken heart that I tell you that we lost our precious Zeus on April 8. He was 14 1/2 years old and was battling liver cancer. However, words cannot adequately convey the benefit of the liver supplements that we ordered from you. We are convinced that they gave him comfort and extended his life. We are forever grateful.

Great service. Pet meds arrived promptly.

Seems to have helped our 12 year old dog

Our dog was diagnosed with Cushing's Disease & very high liver enzymes over a year ago. We use prescribed medicine & this supplement, & her liver enzymes are close to normal. There is no cure, but these treatments have given her an improved quality of life.

Silymarin Advanced For Cats

My cat has been on this for 30 days now. The availability issues with the D brand was why I tried this. I, too, won't know it's effectiveness until blood work is done again.

Approved by my local veterinarian when presented to him as an alternative

No purging of pill at all! (My cat used to purge the D brand half of the time. And, sometimes, the blue casing would be purged 12hrs later)

Pill is slightly larger

Earthy/vitamin smell is present. (I use a pill paste for easy swallowing)


Not sure if it's working or not - will need blood work to see. My dog isn't a big fan of the flavor but will take it with peanut butter.


It seems to be working but I need new blood work on my boy to see if there is improvement.
I will update at that time.

Silymarin Advanced

Very pleased with this product. I love that it is chewable & not needed to be disguised with peanut butter or another tempting product.
Also great price.

Awesome price

A great generic for D***** (product name hidden) at a fraction of the price.

Well Made product

Overall I think this a good product .

Great Price

The price is right compared to the (D..........n). It is small enough to slide down the throat. It seems like the other is always out of stock so this is a good go to. My vet says my girl will need this med for life to protect her liver, so I will be buying this.

2 Dog Owner

Both of my dogs take this medication as a substitute for the original prescription and whenever their liver is checked it is well within the normal ranges. Delivery is fast and this product is a lot cheaper than the original prescription. My vet also strongly approves of this product.

2 Dog Owner

Both of my dogs take this product and they are within the normal ranges when my vet checks their liver. My vet also gives a five star-rating on this alternative as a substitute for the normally prescribed medication. Fast delivery and a lot cheaper than the original prescription.

Dog owner

Great and cheaper substitute for D***** (product name hidden). Came in the mail very quickly!

Dog owner

Quick service

D***** (product name hidden) Substitute

I have been purchasing the Silymarin (D*****) substitute from Vetito ever since the D***** became scarce.

The product works great!

SilymarinAdvanced for Liver

This product works great, and is priced lower than the name brand which had become hard to find.
Apologies for a previous review I left for a different medication for Cushings.

Great product

When D***** (product name hidden) was hard to find, I switched to this product. My vet approved it and it is definitely more affordable.

Silymarin Advanced for Cushings

My dog needs a 10mg dose twice per day. This 20 mg formula is not only specific for him, but the price is a whole lot less than buying the name brand. (less than $200 compared to almost $1000 for 6 months)

Seem to work but shape not so great

The pills seem to be tolerated by my dog as long as they are wrapped in something yummy. The round shape makes it harder to stick in treats or pill pockets. A more oblong or capsule shape would be easier.

Nice to have an alternative

This is the same formula as the brand the vet prescribed at a lesser price than that brand, plus the other brand is often on backorder. So far, this has always been available.

Great for my cat & Budget

I had been using another product “D**” that was more expensive & recently stopped being made. SilymarinAdvanced helps with my cat’s liver function, his blood tests showed lower ALT levels.

Silymarin Advanced

I am very happy I found Vetito & Silymarin Advanced. I had been using a similar pill "D***" that was more expensive and recently the company stopped stocking it. The pill is not coated & I think that makes it "easier" to get in my cat. It's tough to pill a cat but so far Silymarin Advanced has been easy to give and my cat doesn't throw it up. Would definitely buy it again.

Silymarin Advanced

Great substitute for D***** (product name hidden), pill is smaller and doesn't smell as bad. My dog gobbles it right up in a Pill Pocket!

Silymarin Advanced

Ordered this when D***** (product name hidden) was unavailable for my small Pom. The price is about half what I was paying. Tablet a bit larger but I wrap it in a small amount of ground beef and he has no problems swallowing.

Good Substitute for D***** (product name hidden)

Cost is less than 1/2 the price of D*****

Good product, but a little hard to swallow

Because it's not coated and not oblong like D***** (product name hidden), it's a little harder to get my dog to swallow it. I coat it in a little peanut butter, trying to keep it to a minimum.

good price

Appears to work as well as the name brand and much cheaper

Good for my dog!

I got up early to give this to my dog on a empty stomach. Hopefully since we were consistent his counts will be better on the next blood test. This was recommended my my Veternarian. I completely trust her so I trust it will help.

Great Product!

I like that they have combined 2 pills in to one. And its less expensive.


My dog had taken D***** (product name hidden) for years but I was having trouble getting it. So glad I found this replacement! Easier to administer and a much better price!

Good replacement for D***** (product name hidden)

I ordered this for my dog that has been on Denamarin for a long time. There were supply issues and it was impossible to get, so I couldn't help but try this. I really like it, my dog finds it easier to swallow and I like that it doesn't turn my fingers blue. Great supplement at a fair price!


Works great

Excellent product!

Three of my 5 dogs have been on D***** (product name hidden) for a long time. When that became hard to find and more expensive, I luckily discovered Silymarin Advanced with exactly the same ingredients! So pleased with the price, super quick shipment and great customer service.

Good supplement for liver health

We use this supplement for our Westie with hepatitis. Works well and cost less than the version available from our vet

Great product!

My dog seems to be doing just fine with this. Twice a day. It helps his stomach condition greatly. Thanks!

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SAME + Silybin + Phosphatidylcholine All in 1 Tablet. Nutritional supplement to support liver and brain health.

Species: Dog Cat
FREE shipping over $49
Ships Free!
Autoship available
during checkout


SAME + Silybin + Phosphatidylcholine All in 1 Tablet. Nutritional supplement to support liver and brain health.

Species: Dog Cat
FREE shipping over $49
Ships Free!
Autoship available
during checkout
Product images:

Product description

SilymarinAdvanced is a liver and brain health supplement for dogs and cats that contains S-Adenosyl methionine (SAM-e), Silybin (Milk Thistle) and Phosphatidylcholine.

S-Adenosylmethionine, commonly known as "SAME" plays an important role for the wellbeing of your pet's brain and has a key metabolic function in the liver.

Silymarin is a complex mixture of molecules, including Silybin A+B, that have an anti-inflammatory, anti-fibrotic and protective effect on the liver.

Active ingredients

Active ingredients for each 1 tablet.

For Cats & Small Dogs up to 12 lbs:

  • S-Adenosyl methionine (SAM-e) 90 mg
  • Silybum marianum dry extract (Milk Thistle) 31 mg
  • Phosphatidylcholine 60 mg
  • Providing a minimum of 9 mg of Silybin A+B

For Medium Dogs 13 to 34 lbs:

  • S-Adenosyl methionine (SAM-e) 225 mg
  • Silybum marianum dry extract (Milk Thistle) 82 mg
  • Phosphatidylcholine 160 mg
  • Providing a minimum of 24 mg of Silybin A+B

For Large Dogs 35 lbs and over:

  • S-Adenosyl methionine (SAM-e) 425 mg
  • Silybum marianum dry extract (Milk Thistle) 120 mg
  • Phosphatidylcholine 234 mg
  • Providing a minimum of 35 mg of Silybin A+B

Indications for use

The combination of S-Adenosylmethionine, Silybin and Phosphatidylcholine offers your dog or cat a complete and effective approach to liver support. These 3 unique active ingredients are known for their efficacity in:

  • Liver failure
  • Liver disease
  • Brain health
  • Cognitive decline
  • Heart condition
  • Hormones

Administration and dosage

For Cats & Small Dogs:

    Up to 12 lbs   12 lbs and over
Cats   1 Tablet daily   1 Tablet twice daily
Dogs   1 Tablet daily   Use SilymarinAdvanced for Medium Dogs


For Medium Dogs:

    13 to 34 lbs
Dogs   1 Tablet daily


For Large Dogs:

    35 to 65 lbs   66 to 120 lbs   121 lbs and over
Dogs   1 Tablet daily   2 Tablets daily   3 Tablets daily


For optimal absorption:

  • Give tablets on an empty stomach, 1 hour before the meal or 2 hours after the meal
  • Do not split, break or crush the tablets
  • Administer the tablets directly into the mouth
  • Store in a cool dry area away from direct sunlight
Manufactured by Vet Perfect. Shop all SilymarinAdvanced products
Categories: Liver Brain