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Diroban

For the treatment of heartworm disease

Species: Dog
Prescription required
FREE shipping over $49
Ships Free!
Manufactured by Zoetis .
Categories: Heartworm

Diroban

For the treatment of heartworm disease

Species: Dog
Prescription required
FREE shipping over $49
Ships Free!
Product images:
Manufactured by Zoetis
Categories: Heartworm

Product description

Diroban is a sterile powder for injection for use in dogs.

Active ingredients

  • Diroban contains:

    • Melarsomine dihydrochloride 50.0 mg
    • Glycine USP 33.75 mg
  • When reconstituted with the provided 2 mL of Sterile Diluent(sterile water for injection), 1 vial contains:

    • 25 mg/mL of active ingredient

Indications for use

Diroban is indicated for the treatment of stabilized Class 1a , 2b, and 3c heartworm disease caused by immature (4 month-old, stage L5) to mature adult infections of Dirofilaria immitis in dogs.

Administration and dosage

  • Diroban should be administered by deep intramuscular injection ONLY in the epaxial (lumbar) muscles in the third through fifth lumbar region (see graphic). DO NOT ADMINISTER AT ANY OTHER SITE.

  • Avoid superficial injection or leakage. Use a 23 gauge 1 inch needle for dogs equal to or less than 10 kg (22 lb) in weight. Use a 22 gauge 1½ inch needle for dogs greater than 10 kg (22 lb). Use alternating sides with each administration.

  • If repeated administrations are warranted avoid injecting at the same lumbar location. Record the location of the first injection(s) in the patient’s medical record for future reference.

  • Class 1 and 2:

    • If necessary, dogs should be stabilized prior to treatment. Diroban should be administered intramuscularly in the lumbar (L3 - L5) muscles at a dose of 2.5 mg/kg twice, 24 hours apart (see Dosing Table). Four months following treatment, a second treatment series (2.5 mg/kg twice, 24 hours apart) can be elected taking into consideration the response to the first Diroban treatment and the condition, age, and use of the dog. Worms that were too young to be killed by the first treatment series, i.e., < 4 months, may be killed by a second treatment series.
  • Class 3:

    • Alternate Dosing Regime: Dogs with severe (Class 3) heartworm disease should be stabilized prior to treatment and then dosed intramuscularly in the lumbar (L3 - L5) muscles with a single injection of 2.5 mg/kg then approximately 1 month later with 2.5 mg/kg administered twice 24 hours apart (see Dosing Table).
  • Dosing Table:

    • Care must be taken to administer the proper dose. Accurately weigh the dog and calculate the volume to be injected based on the dose of 2.5 mg/kg (1.1 mg/lb). This is equivalent to 0.1 mL/kg (0.045 mL/lb). The following table should be used as a guide to ensure that the proper volume has been calculated.
Weight (lb) Volume per injection (mL)
2.2 0.1
4.4 0.2
6.6 0.3
8.8 0.4
11 0.5
13.2 0.6
15.4 0.7
17.6 0.8
19.8 0.9
22 1.0
44 2.0
66 3.0
88 4.0
110 5.0

Prescribing information

picture_as_pdf Diroban