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Tildren

For the control of clinical signs associated with navicular syndrome

Species: Horse
Prescription required
FREE shipping over $49
Ships Free!

Tildren

For the control of clinical signs associated with navicular syndrome

Species: Horse
Prescription required
FREE shipping over $49
Ships Free!
Product images:

Product description

Tildren is a bisphosphonate drug for intravenous infusion for use in horses only.

Active ingredients

Each vial of Tildren contains:

  • Tiludronic acid (as tiludronate disodium) 500 mg
  • Mannitol USP (excipient) 250 mg

Indications for use

Tildren is indicated for the control of clinical signs associated with navicular syndrome in horses. Navicular syndrome is the most common cause of chronic forelimb lameness in performance horses. It is a degenerative process instigated by mechanical forces.

Administration and dosage

  • A single dose of Tildren should be administered as an intravenous infusion at a dose of 1 mg/kg (0.45 mg/lb).

  • The infusion should be administered slowly and evenly over 90 minutes to minimize the risk of adverse reactions.

  • Maximum effect may not occur until 2 months post-treatment.

Tildren direction for administration:

  • Do not reconstitute or mix Tildren with calcium containing solutions or other solutions containing divalent cations such as Lactated Ringers as it may form complexes with these ions.

Step 1: Preparation of the reconstituted solution (20 mg/mL):

  • Tildren should be reconstituted using strict aseptic technique.

  • Remove 25 mL of solution from a 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP and add it to one vial of Tildren.

  • Shake gently until the powder is completely dissolved. This reconstituted solution contains 20 mg of tiludronate disodium per mL.

  • After reconstitution further dilution is required before administration.

Step 2: Preparation of the solution for infusion:

  • Using strict aseptic technique, withdraw the appropriate volume of the reconstituted solution based on the horse’s body weight (see Table 1 below).

  • Inject that volume back into the 1 liter bag of sterile 0.9% Sodium Chloride Injection, USP. Horses greater than 1,210 lbs. will require a second vial of reconstituted Tildren solution.

  • Invert the infusion bag to mix the solution before infusion. Label the infusion bag to ensure proper use.

  • After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36-46° F (2-8° C) and protected from light.

Step 3:

  • Administer for infusion through a suitable intravenous catheter inserted into a jugular vein and connected to the infusion bag using sterile disposable infusion tubing.

  • Dosing Table

Weight Range (lbs) Volume of Reconstituted TILDREN Solution (20 mg/mL) to be added to the infusion bag
550-770 15 mL
771-990 20 mL
991-1210 25 mL1
1211-1430 30 mL (25 mL1+ 5 mL from additional vial)
1431-1650 35 mL (25 mL1+ 10 mL from additional vial)
1651-1875 40 mL (25 mL1+ 15 mL from additional vial)

  1. 1 vial = 25 mL